ANTI-AGING
01. What is a Revive PeptideTM?
01. What is a Revive PeptideTM?
① Revive PeptideTM
Two types of Plmitoyl-Matrikine consist of Palmitoyl-Gly-His-Lys and Palmitoyl-Gly-Pro-Arg.
② Matrikine
It is a extracellular matrix-derived peptides that interacts with a specific receptor in a cell to regulate cell activity.
③ Characteristics of peptide compounds
It acts on the papillary layer of the dermis, which is easily damaged by ultraviolet rays, and helps the skin to recover.
It reduces wrinkles, promotes skin tone and elasticity of the skin.
It activates the genes of cells and extracellular matrix required for cell proliferation and differentiation.
Structure of Revive PeptideTM
Palmitoyl-Gly-His-Lys
Palmitoyl-Gly-Glu-Pro-Arg
02. In vitro test of Revive PeptideTM
① Extracellular matrix synthesis
It is confirmed that the synthesis of fibroblast cells and extracellular matrix increase when they are cultured for 72 hours with addition of peptide (0.5ppm, 1.5ppm, 2.5ppm).
② Stimulation of gene expression
It is demonstrated that Matrikine stimulates the expression of dermal and epidermal genes using DNA-array technology on in vitro epidermal and fibroblast culture.
Increased extracellular matrix synthesis by peptide compound
03. In vivo test of Revive PeptideTM
① Restoration of dermal papillary layer
The 28 female participants aged 51-72 years old (mean age 59 years old) applied a revive peptide 2.5ppm mixed cream on half of the face and forearm (inside and UV irradiated outside). It has been confirmed that the fiber divisions are reduced and the fiver network regeneration of the dermal papillary layer is increased.
② SLEB (Subepidermal Low Echogenicity Band) Analysis
Check for improvement of SLEB index after 1 month.
viscosity -5.5%/control density +7.8%/control age improvement of -1.8 years old
SLEB(Subepidermal Low Echogenicity Band) Test ( upper: normal epidermis and dermis layer, below: epidermis and dermis damaged by UV irradiation )
Day 0: epidermis & dermis layer become thin.
Day 28: Recovery of epidermal and dermal damage
Improvement of SLEB index after 28 days
04. Collagen Retention Network
The 28 female participants aged 51-72 years old (mean age 59 years old) applied a revive peptide 2.5ppm mixed cream on half of the face and forearm (inside and UV irradiated outside). It has been confirmed that the fiber divisions are reduced and the fiver network regeneration of the dermal papillary layer is increased.
VIVASCOPE
VIVASCOPE Measure
Day 0
Day 28
Fiber network regeneration of dermal papillary layer: 13.9% ~ 54% improvement (p < 0.01, 71% of participants)
05. Wrinkle reducing effect, and skin tone & elasticity improvement
For 23 female participants between the ages of 42 and 67, we applied a revive peptite 2.5ppm mixed cream on one side of face twice a day for two months.
Efficiency analysis using Profilometry Cutometry, and Photography confirmed that wrinkles, skin elasticity and skin tone are improved.
Before
After
Profilometry, Cutometry & Photography Analysis