KOR

ANTI-AGING

01. What is a Revive PeptideTM?

01. What is a Revive PeptideTM?

① Revive PeptideTM

Two types of Plmitoyl-Matrikine consist of Palmitoyl-Gly-His-Lys and Palmitoyl-Gly-Pro-Arg.

② Matrikine

It is a extracellular matrix-derived peptides that interacts with a specific receptor in a cell to regulate cell activity.

③ Characteristics of peptide compounds

It acts on the papillary layer of the dermis, which is easily damaged by ultraviolet rays, and helps the skin to recover.

It reduces wrinkles, promotes skin tone and elasticity of the skin.

It activates the genes of cells and extracellular matrix required for cell proliferation and differentiation.

Structure of Revive PeptideTM

  • Palmitoyl-Gly-His-Lys

  • Palmitoyl-Gly-Glu-Pro-Arg

02. In vitro test of Revive PeptideTM

① Extracellular matrix synthesis

It is confirmed that the synthesis of fibroblast cells and extracellular matrix increase when they are cultured for 72 hours with addition of peptide (0.5ppm, 1.5ppm, 2.5ppm).

② Stimulation of gene expression

It is demonstrated that Matrikine stimulates the expression of dermal and epidermal genes using DNA-array technology on in vitro epidermal and fibroblast culture.

Increased extracellular matrix synthesis by peptide compound

03. In vivo test of Revive PeptideTM

① Restoration of dermal papillary layer

The 28 female participants aged 51-72 years old (mean age 59 years old) applied a revive peptide 2.5ppm mixed cream on half of the face and forearm (inside and UV irradiated outside). It has been confirmed that the fiber divisions are reduced and the fiver network regeneration of the dermal papillary layer is increased.

② SLEB (Subepidermal Low Echogenicity Band) Analysis

Check for improvement of SLEB index after 1 month.

viscosity -5.5%/control density +7.8%/control age improvement of -1.8 years old

  • SLEB(Subepidermal Low Echogenicity Band) Test ( upper: normal epidermis and dermis layer, below: epidermis and dermis damaged by UV irradiation )

  • Day 0: epidermis & dermis layer become thin.

  • Day 28: Recovery of epidermal and dermal damage

Improvement of SLEB index after 28 days

04. Collagen Retention Network

The 28 female participants aged 51-72 years old (mean age 59 years old) applied a revive peptide 2.5ppm mixed cream on half of the face and forearm (inside and UV irradiated outside). It has been confirmed that the fiber divisions are reduced and the fiver network regeneration of the dermal papillary layer is increased.

  • VIVASCOPE

  • VIVASCOPE Measure

  • Day 0

  • Day 28

Fiber network regeneration of dermal papillary layer: 13.9% ~ 54% improvement (p < 0.01, 71% of participants)

05. Wrinkle reducing effect, and skin tone & elasticity improvement

For 23 female participants between the ages of 42 and 67, we applied a revive peptite 2.5ppm mixed cream on one side of face twice a day for two months.

Efficiency analysis using Profilometry Cutometry, and Photography confirmed that wrinkles, skin elasticity and skin tone are improved.

  • Before

  • After

Profilometry, Cutometry & Photography Analysis

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