WHITENING
01. Skin Whitening and Natural Extract
The botanical whitening active ingredient inhibits tyrosine kinase, the main enzyme of melanogenesis,
as well as inhibits melanin production from melanocytes.
Due to the "Dual-Mechanism" of these botanical whitening active ingredients, it keeps the blackened skin healthy, clear and white skin.
Skin whitening and whitening complex™
02. Melanin Production Inhibition Evaluation
Melanoma cells were cultured in the presence of GluCA® and the total amount of melanin
synthesized in the cells was reduced by 37% compared to non-treatment group as a control.
Analysis of total melanin levels in melanoma cells treated with GluCA®
*represents a statistically significant difference between the treated and the control (p < 0.05)
03. Tyrosinase Inhibition Test
The inhibitory effect of tyrosinase, the most important enzyme of melanin synthesis,
examined in melanoma cells treated with GluCA®.
That is, 69%, 51% and 48% inhibition of enzyme activity was observed in the treatment groups of 1 μg/ml, 5 μg/ml and 10 μg/ml, respectively.
Tyrosinase inhibition assay by GluCA®
*represents a statistically significant difference between the treated and the control (p < 0.05)
04. Skin Whitening Effects Evaluation
GluCA® Cure has proven the whitening, regeneration & restoration of melanin pigmentation skin by a variety of causes
through three-dimensional melanocyte cell culture experiments and skin clinical testing
Evaluation of the whitening effects of natural extracts
Melanin accumulation - purple
Contrast group
UV B
UV B + Natural extract
Skin Whitening Clinical Efficacy Assessment
GluCA® Melanin pigment inhibition
Before use
After 4 weeks
After 8 weeks